تقييم النشاطية البيولوجية والفعالية العالجية لمستخلص راتنج نورات نبات لبان عزايز النامي في منطقة وادي سوف

Abstract

Atractylis flava, locally known as “Lban Azaïz,” is a medicinal plant traditionally used in Algeria, particularly for treating urinary and gastric pain. Although some studies have investigated its general phytochemical composition, the plant's resin extracted from the inflorescences has not been sufficiently explored from a biological perspective. This study aims to evaluate the biological activity of the resin extracted from the inflorescences of Atractylis flava, using a series of in vitro and in vivo assays. The resin was extracted with 97% ethanol following an initial maceration in an alkaline aqueous medium (pH = 10). The results revealed weak antioxidant activity (DPPH: IC₅₀ = 0.624 mg/ml) and moderate anti-inflammatory activity (BSA: IC₅₀ = 1.156 mg/ml). In contrast, the resin exhibited a notable analgesic effect (Hot Plate: 24.54 s; Writhing test: significant reduction in abdominal writhes), as well as a promising antidepressant effect (TST: 277.18 s; FST: 269.68 s), and a gastro protective effect, with an ulcer inhibition rate of 64.85%. These findings highlight the resin’s promising biological value and support its potential as a natural source for developing safe and effective therapeutic alternatives.