Epidemiological study, predictor factors and prognostic significance of blood biomarkers in El-Oued breast cancer patients

Abstract

Breast cancer is the most frequent cancers for woman and represents the first cause of cancer death for woman, in this perspective the aim of our work is carried out an epidemiological study, evaluation of some risk factors and biological markers in patients with breast carcinoma in El Oued region. Our epidemiological study was carried out on 1505 cancer patients in the period (2007-2017) of the El Oued region obtained from Oncology service of the hospital Ben Amor Djilani and El Fajer association for breast cancer-El Oued. So 100 women (50 healthy women and 50 breast cancer patients) were used to study socio-clinical risk factors and 36 control and cancerous woman for biological markers study (biochemical, minerals and oxidative stress) for screening and follow-up breast cancer. The results of epidemiological study, show that several types of cancer are marked in different region of El Oued state and that breast, intestine and lungs cancer are the most dominant (24.91%, 10.98 % and 8.57%) respectively, age 41-60 years and women sex are most affected by diseases. for breast cancer, 375 cases were recorded, 28.95% patients were aged between 41-50 years, 2% of breast cancer are in men versus 98% are in women. In this study, 48% of the breast cancer patients had a tumor affecting the right breast whereas 52% in the left breast. Our study reports shows a strong association between socioeconomic behavior (such as passive smoking, Sunshine exposed...) and clinical history (such as Chronic diseases, contraceptive pulls...) with breast cancer but remains the Phone in Bras and Fast Food the most dangerous risk factor, (OR = 31.06, OR =19.05) respectively, for breast cancer. While Spices and breastfeeding more than 8 months are important protective factors against this disease. Biological study shows a remarkable change of hematological, oxidative stress and some minerals markers and GSH in erythrocyte (AUC=0.93), leukocyte (AUC=0.875) and salivary (AUC=0.732) and serum ORAC (AUC=0.823) more susceptible to disease. Increase of serum lead level in patients (more than 18 times than controls) is an important indicator of the effect of the environment on the disease. In conclusion, Several socioeconomic, clinical and environmental factors contributed to the dispersion and development of the breast cancer in the region of El-Oued, suggesting that GSH and ORAC testing be used as systematic markers for screening and followed breast cancer treatment.