Study of risk factors and some biochemical, hematological, hormonal and oxidative stress markers to predict and follow up of gestational diabetes women in El-Oued region

Abstract

Gestational Diabetes Mellitus (GDM) is one of the most common pregnancy complications, has increased by more than 30 (%) within one or two decades in a number of countries forming an emerging worldwide, the aim of our work is to evaluate some risk factors and biological markers and stress oxidative status for determining some predictive factors of GDM in patients of El Oued region. Our socioeconomic risk factors study was conducted on 140voluntary women divided into70 healthy women, mean age 546.82±760.0years and 70 GDM patients mean age .86..4±760.. years. For biological study, we have selected 15 healthy control mean age 27.67±1.77years and 15 women GDM patients mean age 34.64.± 1.03 years. Some biochemical, hematological, trace elements, hormonal and oxidative stress markers were analyzed in our study. The results of risk factors study illustrate the high relationship between some socioeconomic comportments such as passive smoking, social problems and clinical factors such as obesity, contraceptive pills and gestational diabetes, but family history and chronic disease are the most dangerous risk factors, (OR =58.10, OR =33.22) respectively, for GDM. While sports and daily activity are important protective factors against this disease. For biological study, our results reveal a significant change (P<0.05) of hematological, biochemical, hormonal, oxidative stress and some minerals markers in GDM patients as compared to control, with a significant (P 0.05) relationship between the changes of both thyroid hormones (T3 and TSH) and the oxidative stress markers ( MDA , CAT and ORAC) on the one hand and the changes in levels of serum zinc and serum copper and the level of oxidative stress in both GDM with and without pregnancy on the other6From this study we found that some of oxidative stress markers have a high sensitivity, specificity and AUC values which qualify them to be important markers for diagnosing and predicting Gestational diabetes disease in women. Finally, we conclude that there are a most socioeconomic and clinical risk factors and predictive factors for GDM disease. Also a change in the serum level of thyroid hormones and the level of mineral elements in relation with oxidative stress of women with gestational diabetes contributes to the development or complication of the disease after pregnancy