Epidemiological Study and Prognostic Value of Some Biochemical, Hematological and Oxidative Stress Markers to Follow up and Prevent Complications of Hepatitis B in Patients of EL-Oued Region

Abstract

Viral hepatitis is one of the most important liver diseases and is a viral infection that affects the liver and can cause acute and chronic diseases. The aim of our work is carried out an epidemiological study and evaluation of biological and oxidative stress markers in patients with hepatitis B in El-Oued region. Our epidemiological study was carried out on hepatitis patients admitted to Ben Omar Djilani hospital in the period between January 2013 to December 2020 in Wilaya of El-Oued. Our biological markers study was conducted on 30 voluntary divided into healthy (controls) and patients group, they were used to study the hematological , Biochemical and oxidative stress markers, for screening and follow-up hepatitis. The results of the epidemiological study showed that 1798 cases of hepatitis infection were registered. 72.14% of them were aged between 20 to 40 years. On the other hand, 57.30 % of hepatitis patients are men versus 42.70% are women. In this study, 95% of the patients were infected with hepatitis B whereas 5% were infected with hepatitis C. Concerning the distribution of hepatitis, the eastern and central region include the highest numbers of patients with 37% and 33% respectively. For the biological study, our results revealed a significant change ( p< 0,05 ) of some hematological , biochemical and oxidative stress markers in hepatitis B patients as compared to controls. From this study we found that some of oxidative stress markers have a high sensitivity, specificity and AUC values which qualify them to be important marker for follow up and predicting complication of hepatitis B. On one hand this study showed a significant (p<0,05) relationship between the changes of some specifics oxidative stress markers with some hematological and biochemical markers. In conclusion, the change in hematological , biochemical and their relationship with oxidative stress contributes to the development or complication of the disease after hepatitis. Suggesting that MDA, GSH, CAT, SOD and ORAC testing used as systemic marker for screening and followed hepatitis B treatment.