Preparing for a cream from natural oils Ammi majus, Glycyrrhiza glabra, Salvia officinalis to reduce the effects and symptoms of psoriasis

Abstract

This study aimed to develop and evaluate a natural topical cream based on oil extracts from three medicinal plants Glycyrrhiza glabra (licorice), Salvia officinalis (sage), and Ammi majus with potential application in reducing the effects and symptoms of psoriasis. Each plant was selected based on its phytochemical profile and traditional therapeutic use. The oils were extracted by steam distillation and incorporated into a cream formulation, which was then subjected to a series of analytical and biological tests. Antioxidant activity was assessed via DPPH assay, revealing notable radical-scavenging capacity. demonstrated a notable inhibitory effect compared to the standard antioxidant ascorbic acid. The extract exhibited a progressive increase in inhibition percentage, reaching approximately 70% at the highest tested concentration (160 mg/ml), with an IC₅₀ value of 18.929 mg/ml. Antimicrobial activity was evaluated using the agar well diffusion method against E. coli, S. aureus, and C. albicans, showing significant inhibitory zones, particularly for Ammi majus. Physicochemical evaluation confirmed that the cream had appropriate pH, smooth texture, and stable homogeneity under microscopy. In vitro SPF testing placed the product in the “low protection” category (SPF = 3.38), recommending its use under non-sunlight conditions. Finally, clinical application on eight psoriasis patients over 20–30 days demonstrated visible symptomatic relief, reduced inflammation, and improved skin quality. These findings highlight the potential of plant-based formulations as complementary dermatological therapies.